Archive for the ‘Inside the Lab’ Category

Zika Virus: What should infertility patients do?

January 31, 2016Carole 2 Comments »

NEW UPDATE FROM ASRM REGARDING ZIKA VIRUS AND REPRODUCTION (as of 4/6/2016): Open pdf from this link: The guidance  in the pdf is for providers but I think patients should be aware of the recommendations that professional societies are giving to medical providers so that they can be sure they are getting the best […]

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INVOcell- Analysis of Risk vs Benefit

November 11, 2014Carole 2 Comments »

Just the other day, I stumbled across an article published on Oct 24, 2014 that discussed a oral presentation presented at the recent ASRM meeting about a low cost IVF alternative called INVOcell. To my surprise, I found comments I made more than two years ago appearing in the current article although no one actually […]

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Izumo, Meet Juno: fertilization receptors revealed

April 19, 2014Carole 6 Comments »

Unexplained infertility is the diagnosis that women (and men) get when everything looks normal but they can’t conceive. A recent study published in Nature this month may go a long way to explaining some of this unexplained infertility. Dr. Gavin Wright and his team at the Welcome Trust Sanger Institute in Britain have identified a […]

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Post-Thaw Evaluation of Embryos

March 23, 2014Carole 151 Comments »

I received this email from a reader who wanted to know more about the process for thawing and assessment of embryos that have been cryopreserved. This last cycle involved a FET of a day 5 and day 6 blastocyst from an earlier IVF that we were not able to complete a transfer for.  The embryos […]

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Preimplantation Genetic Testing -Barriers to its use and development

March 21, 2014Carole 11 Comments »

Amy Klein, who writes the Fertility Diary column at the New York Times and blogs at In Vitro. wrote a provocative Slate article, Embryo Testing Should Not be Controversial:Fears of designer babies,eugenics, and abortion are inhibiting research and medicine .which takes up some of the barriers to societal acceptance and full technical optimization of embryo […]

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Q from U: Fertilization in the wild… and in the dish

February 16, 2014Carole 8 Comments »

I received this question from a reader this morning and it seemed like a great topic for my “Q from U” Series. I obviously know the basics (of fertilization), but I recently found out that a just ejaculated sperm can not immediately fertilize an egg. How much time and what does the sperm go through […]

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What makes an IVF program excellent?

August 27, 2013Carole 4 Comments »

Previously published on-line . Journal of Clinical Embryology. Vol.16 . Issue 3. pp.166-167 ( Patients are always asking me, “How can I find an excellent IVF program?” I usually tell them to review the annual outcome data that IVF programs report to the CDC or SART and look for programs with better than average live […]

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Blastocoel fluid as a DNA source for PGD/PGS

April 17, 2013Carole No Comments »

In the most current issue of Reproductive Biomedicine Online, IVF researchers in Europe (S. Palini, L. Galluzzi, S. De Stefani, M. Bianchi, D. Wells, M. Magnani, C. Bulletti) have reported  in their paper “Genomic DNA in human blastocoele fluid”,(DOI: 10.1016/j.rbmo.2013.02.01) that: 1) they were able to recover embryo DNA from the fluid-filled center (the blastocoel) […]

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Determining Best Practices in ART: A call for new ideas

July 12, 2012Carole No Comments »

(Originally published in Journal of Clinical Embryology, Spring 2012) Assisted Reproductive Technology (ART) is a curious blend of medical practice and scientific technical expertise. Unlike much of medical practice, fertility treatment involves not only the patient’s body and physician’s expertise but also the skills of laboratory technicians to produce healthy embryos. As embryologists readily acknowledge, […]

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Can ovarian stem cell technology replenish ovarian reserve?

July 3, 2012Carole 17 Comments »

The short answer to the title question is, that Yes!, we are getting considerably closer to achieving therapeutic applications of stem cell technology to replenish ovarian reserve. Dr. Jonathan Tilly and his colleague Dr. Dori Woods recently summarized the dramatic advances in ovarian stem cell technology in their paper “The next  (re) generation of ovarian […]

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