Archive for the ‘Repro Bio 101’ Category

DNA repair gene mutations may explain declining ovarian reserve

February 17, 2013Carole No Comments »

Poor DNA repair may be the key to both cancer and egg aging, according to a new study.  “I think we have found a general theory of reproductive aging,” said Kutluk Oktay, a fertility specialist at New York Medical College and co-author of  “Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in […]

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Useful embryo pictures for both patients and embryologists

February 11, 2013Carole 1 Comment »

Sometimes a picture really is worth a thousand words, especially when you want to understand the microscopic world of embryology. The European Society of Human Reproduction and Embryology (ESHRE) recently published the Atlas of Human Oocytes and Embryos and have made it available for free on-line in either HTML or PDF form. Click on the […]

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A possible molecular basis for recurrent miscarriage identified

January 16, 2013Carole No Comments »

When we think of infertility, we immediately think about the problem of not being able to get pregnant. But getting pregnant is not the same as having a child. The other end of the sharp stick in the eye that is infertility is the problem of getting pregnant- sometimes easily- but not being able to […]

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Creation of “virtual” children identifies risky sperm donor genomes for recipients

December 17, 2012Carole 7 Comments »

What characteristics  do you want in your sperm donor? Blue eyes? Brown hair? Would you like a six-foot two medical student who loves to play the saxophone or a five foot seven blonde tennis player? Or perhaps you’d like to find a sperm donor whose characteristics are a good match for your husband? Being able […]

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The link between Cystic Fibrosis and infertility

November 14, 2012Carole 2 Comments »

Andrologists performing semen analysis sometimes encounter  patients with no sperm in their ejaculate. There can be many reasons for “shooting blanks” ; the sperm factory could be closed (spermatogenesis failure) or the plumbing could be blocked (previous scarring from infection or a vasectomy) or the plumbing could actually be missing. The tubing that connects each […]

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Developing a better crystal ball to predict IVF success: IVF prediction software

November 2, 2012Carole 4 Comments »

Before we start down the road to IVF, is there a way to determine the probability that IVF treatments will work for us? Is there a way to predict our risk of multiples when we are being asked to decide between transferring one or two…or even three embryos? I failed my first IVF, what are […]

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Can ovarian stem cell technology replenish ovarian reserve?

July 3, 2012Carole 17 Comments »

The short answer to the title question is, that Yes!, we are getting considerably closer to achieving therapeutic applications of stem cell technology to replenish ovarian reserve. Dr. Jonathan Tilly and his colleague Dr. Dori Woods recently summarized the dramatic advances in ovarian stem cell technology in their paper “The next  (re) generation of ovarian […]

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Q From U: Human IVF Culture Medium

June 10, 2012Carole 1 Comment »

From a reader this week: I was wondering about the culture that is used to put the embryos in. I know nothing about it and got curious. My clinic had to get some particular culture/medium in so they could do day 3 vitrification and it got me thinking. What is the culture? What is it […]

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Epididymis: where sperm get fine tuned and functional

June 8, 2012Carole 4 Comments »

In honor of the up-coming Father’s Day, I thought I’d tell the story of a little known but highly significant male reproductive organ- the epididymis. It is pronounced Eppie-Diddy-Mus which may sound like an urban rapper but I assure you, it is not.  The epididymis which is attached to and  lies just above the testicle, […]

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Q from U: Embryo Fragmentation

May 18, 2012Carole No Comments »

This week, a reader contacted me regarding fragmentation in her embryos. She was told by her RE that things were looking “good” but then he also mentioned that some of the embryos on day 3 were showing some signs of fragmentation. Her question was how concerning was this observation that her embryos had some fragmentation? […]

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