Comments for Fertility Lab Insider

Comment on Embryo stages, progression and pregnancy outcomes by Kelly rr

Kelly rr — Thu, 20 Jun 2013 07:58:06 +0000

Hi there

Hoping this will be an easy one for you!

I am currently on the two week wait, I had a 5AA blastocyst transferred on Tuesday 18th. I was told it was perfect and couldn’t get any better!? I am 29 years old and our only problem is I have slight pcos. Do you think our chances are good for implantation if the blast was already hatching?

I am pulling my hair out already.

Many thanks in advance

Kelly x

Comment on Embryo stages, progression and pregnancy outcomes by blogspot.com

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Comment on Common practices of the best IVF programs by karen millen red dress

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Comment on Embryo stages, progression and pregnancy outcomes by EllieS

EllieS — Mon, 17 Jun 2013 17:59:03 +0000

Hi Carole
Thanks so much for you reply- you’re very kind to spend your time doing this!

Comment on Embryo stages, progression and pregnancy outcomes by Carole

Carole — Mon, 17 Jun 2013 14:57:38 +0000

Hi SallyB,
Good questions. I have observed compaction occurring with a variable number of cells. I don’t think we understand what the triggers are. The most popular scoring system gives better grades to embryos with more cells at the blastocyst stage but I have seen plenty of pregnancies from embryos with less than stellar scores so not sure how important any of these variables are. There is still much to understand but research with humans is difficult and embryo research is especially difficult to perform so we work by trial and error. Carole

Comment on Embryo stages, progression and pregnancy outcomes by Carole

Carole — Mon, 17 Jun 2013 14:53:37 +0000

Hi Helen,

Re: Today, day four I have 8 morulas, 4 x 12 cells ‘top quality’,. these are actually right on target- morula on day 4 is great. The other 4 my be a little slow but only lagging a day- may still be fine. Your program will probably transfer some of the ones that are morula today because they should be blastocysts on day 5 when you are expecting a transfer. I really can’t estimate how many will make it to freeze but since you are doing real well so far, I’d expect 4-6 to freeze from the 8 morulas, depending on how many are transferred. Depending on program policy, any blastocysts on day 6 may also be frozen.

I am always a fan of SET, if you can afford multiple transfers, since your chance of being pregnant is reduced to one chance per transfer, not two. Like buying two lottery tickets instead of one. Singleton pregnancies are more likely to have fewer, if any, obstetrical complications. I think you are on the right track. Good Luck!!

Comment on Embryo stages, progression and pregnancy outcomes by EllieS

EllieS — Sun, 16 Jun 2013 17:50:30 +0000

Hi Carole
Thank you so much for responding the all of these questions;already the answers from others have helped me understand the process better.
I am 41. Amh 20.1. No known male factor – just my age.
I am having (I hope) a five day transfer tomorrow. I feel I have been blessed with how things have worked to far. I has 15 eggs retreived, 15 fertilised, and still 15 ‘top quality’ with less than 10% fragmentation on day 2.
On day three three embryos had fallen behind to five cells but the lab said that 12 were top quality at their expected 6-8 cells.
Today, day four I have 8 morulas, 4 x 12 cells ‘top quality’,
(should I be thinking these are a bit slow)? , two eight cells (slower again) and one prob arrested and still at 5 cells. They have done assisted hatching on them alll on day 3.
I wonder if you might be able to estimate how many might make it to freeze and also advise if the assisted hatching would help or hinder the freezing process.
Also I understand assisted hatching increases the chance of identical twins so am now wondering if I should consider a single embryo transfer with the hoped-for cushion of FET in the future, the lab says they have a 10% chance of multiples in my age group but I don’t know if that’s not taking assisted hatching into account…
Sorry I know I am fortunate with my numbers so far, I am happy, just such big decisions to make imminently…
Many thanks for any thoughts you can give…

Comment on Embryo stages, progression and pregnancy outcomes by Sallyb

Sallyb — Sun, 16 Jun 2013 07:14:31 +0000

Hi Carole,
What a wonderful, informative site you have. I’m not sure if there is an answer to this question but I was wondering if there is any known reason that embryos begin to compact at different stages. I had an 8 cell transferred on day 3 that was showing no signs of compaction but there was also a 5 cell that was already showing signs of compaction and it went on to become a day 5 blast (now on ice). I would have thought that they would all reach a similar number of cells before being able to advance to the next stage.

Comment on Finding your “Best Fit” IVF Program by Carole

Carole — Fri, 07 Jun 2013 15:03:36 +0000

Hi Anonymous,
Percentages can be somewhat deceiving. A 50% rate in one age group may mean that one patient of two patients in that age group got pregnant or it could mean that they cycled 100 women in that age group and 50 became pregnant. The second percentage would have more weight in my eyes as a better estimate of a “true” rate. So when percentages are provided, especially for few cycles, both numbers (#successes and # attempts) should be disclosed. Actually, if you look at the CDC reports, if fewer than 20 or 50? cycles are reported in a particular age bracket, the rate is reported as a fraction just for this reason. In stats from my labs, I have noticed this blip before and it may be due to patient recruitment. Women who are basically fertile but with diminished reserve (older age group) can do just fine with the hormonal boost from IVF. Sometimes the younger age group may have more individuals in it with more serious problems- they came earlier to treatment because they knew that had multiple hurdles. This could explain the discrepancy of a higher pregnancy rate in an older age group. With larger numbers of cycles, these statistical blips tend to even out. Good Luck!

Comment on Finding your “Best Fit” IVF Program by Anonymous

Anonymous — Fri, 07 Jun 2013 13:30:43 +0000

Thanks for your response! I did ask about the 2012 rates and they did not say they were not available yet. What is so crazy is the 38-40 age bracket above my age group success rates are around 50%! This is 22% highler than the stats for my age bracket. Does that happen often? I am currently on bcp and about to start meds in a few weeks and just had this freak out! I am looking into another clinic in another state that could start monitoring the next cycle. Of course it would be alot easier to just continue with my current clinic that is a minute from my house in a few weeks. I just don’t want to regret not going to a clinic with better stats. Thanks!

Kim