Resume, Carole C. Wegner, Ph.D., HCLD

Education and Training:

Post-doctoral Fellow: Magee-Womens Research Institute, Pittsburgh, Pennsylvania, 2000-2002. Research Area: Interaction between parvovirus B19 and its receptor on placental trophoblast cells; a possible route for maternal-fetal transmission.

Post-doctoral Fellow: Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, Houston, Texas. 1990-1995 Research Area: Uterine function in embryo implantation.

Ph.D.: Physiology (Reproductive Physiology Emphasis) Pennsylvania State University, Degree conferred in August 1990. Dissertation: Estrus-Associated Proteins Synthesized by the Bovine Oviduct.

BSc.: Zoology (Reproductive Physiology emphasis) Kent State University Honors Program, Graduate Cum Laude, May 1985 Honors Thesis:  Purification of B-N-Acetylhexosaminidase from rat caudal epididymal fluid.

Professional Experience

President, Zygote Science, LLC. IVF Consulting and Medical Writing Company. Established February 2, 2010. Publication: Fertility Lab Insider, copyright 2011., available from Amazon.com and Barnes & Nobles Booksellers as an ebook.

Laboratory Director, Carolina Conceptions, Raleigh N. Carolina,  Sept 1, 2011 to January 27 ,2012.

Scientific Director, Advanced Reproduction Institute, Evansville Indiana, 2005-2010.

Director of Embryology/ART, 2005- 2009. Center for Reproductive Biology of Indiana, LLC (CRBI).,Indianapolis, Indiana.

Director of Embryology/ART, Reproductive Biology Laboratory, Clarian Health Partners, Indianapolis, Indiana. 2002-2005.

Assisted Reproductive Technology (ART) Laboratory Director, 1996 – 2000. The Fertility Center at St. Clair Memorial Hospital, Mt. Lebanon, PA.

Chief Scientist, IVF.  Western Pennsylvania Institute for Reproductive Medicine and Technology, Western Pennsylvania Hospital, Pittsburgh, PA.1995- 1996. 

Additional Certification

  • High Complexity Clinical laboratory Director (HCLD), certified by the American Board of Bioanalysis (ABB) effective October 20, 1999. Certificate #7464.
  • Technical Supervisor, certified by ABB in the disciplines of Andrology and Embryology, effective August 3, 1998.
  • College of American Pathologists Inspector Course, CAP inspector # 1026783 (Toronto, Canada; September 24, 1999).

Grants, Awards and Honors:

  • 2010 Top 40 Infertility Blogs award to Fertility Lab Insider  by Medical Billing and Coding.
  • Clarian Values Fund Grant VFR-185 awarded to CCW for the research project: In vitro-culture of Previously Cryobanked Ovarian Tissue”, two-year research grant, awarded May 2005.
  • Reproductive Biology Laboratory won the Consumers Choice Award 2004 for the category of Hospital Infertility and Urology.
  • IVF Team won the Clarian Silver Team Award for reducing supply costs by 25% in one year.
  • Irene McLenahan Young Investigator Research Fund Award: “Interaction between human parvovirus B19 and its globoside receptor on placental trophoblast cells”, ($5000; awarded Jan 1, 2002)
  • Individual National Research Service Award, National Institutes of Child health and Human Development, Award #HD 07568 from May 1992-May 1993.

 

Peer-reviewed Publications:

Wegner, C.C,. Clifford, A.L. Jilbert, P.M., Henry, M.A, Gentry, W.L.  2009 Abnormally high Body Mass Index (BMI) and tobacco use is associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides. Journal of Fertility and Sterility, (93)1:332-334.

Drabiak, K., Wegner, C., Fredland, V., Helft, PR. 2007. Ethics, Law and Commercial Surrogacy: A Call for Uniformity, in the Journal of Law, Medicine and Ethics, Summer 2007. pp. 300-309. (Article cited by Jessica Arons, Dec. 2007 in Center for American Progress Report: Future Choices: Assisted Reproductive Technologies and the Law).

Wegner, C.C. Jordan, J.A. 2004. Human parvovirus B19 VP2 empty capsids bind to human villous trophoblast cells in vitro via the globoside receptor.  Infectious Diseases in Obstetrics and Gynecology, June 2004, (12)2:69-78(10).

Wegner, C.C., Zhou, X.H., Ding, Z-M, Kuo, M.T., Carson, D.D. 1997. Tyrosine kinase inhibition decreases Muc-1 expression in mouse epithelial cells. J. Cellular Physiology 170:200-208.

Wegner, C.C., Cherington, V., Clemens, J.W., Jacobs, A.L., Julian, J., Surveyor, G.A., Bell, E.C., Carson, D.D. 1996. Production and characterization of WEG-1, an epidermal growth factor/transforming growth factor-a-responsive mouse uterine epithelial cell line. Endocrinology 137 (1): 175-184.

Surveyor, G.A., Gendler, S.J., Pemberton, L., Das, S.K., Chakraborty, I., Julian, J., Pimental, RA. Wegner, C.C, Dey, S.K., Carson, D.D. 1995. Expression and hormonal control of Muc-1 by mouse uterine epithelial cells. Endocrinology 136(8): 3639-3647.

Wegner, C.C., Carson D.D. 1992. Mouse uterine stromal cells release a 30-kDa protein in response to co-culture with uterine epithelial cells. Endocrinology 131(6): 2565-2572.

Wegner, C.C., Killian G. 1992. Origin of estrus-associated glycoproteins in bovine oviduct fluid. J. Reprod. Fert 95:841-854.

Wegner, C.C., Killian G. 1991 In vitro and in vivo association of an oviduct estrus-associated protein with bovine zona pellucida. Mol Reprod Dev. 29:77-84.

Killian, G. Honadel, T., McNutt,T., Henault, M., Wegner, C., Dunlap, D. (1989) Evaluation of butylated hydroxytoluene as a cryopreservative added to whole or skim milk diluents for bull semen. J. Dairy Science 72:1291-1295.

Book Chapters:

Wegner, C.C. and Carson, D.D. 1993. Cell adhesion processes in implantation. In: Oxford Reviews of Reproductive Biology Vol. 16. Chapter 3. H.M. Charton, Editor.

Carson, D.D., Julian, J., Liu, S., Rohde, L., Surveyor, G. and Wegner, C.C., 1994. Mucins and proteoglycans as modulators of embryo-uterine epithelial cell attachment. In: Molecular and Cellular Aspects of Preimplantation Processes. New York: Springer-Verlag New York, Inc. 1995. P. 105-112. S.K. Dey, Editor.

Invited Articles:

Wegner, CC. 2012. Determining best practices in ART may require novel approaches: A Call for New Ideas. Journal of Clinical Embryology. Vol. 15. Issue 1. Spring 2012 pp14-16.

Wegner, CC. 2012. The Embryologist’s Role as Patient Educator. Journal of Clinical Embryology. Vol. 15. Issue 2. Summer 2012 pp 32-33.

Wegner, CC. 2012. Aligning the Medical and Business Ethics of your IVF Team. Journal of Clinical Embryology. Vol. 15. Issue 3.Fall 2012. pp 67-68.

Wegner, CC. 2012. ASRM Meeting News: Better decision-making tools are on the horizon for both ART embryologists and patients. Journal of Clinical Embryology Vol 15, Issue 4. Winter 2012 pp 98-99.

Book

Fertility Lab Insider: Your insider’s guide to high tech infertility treatments and taking back control of your health care.

Invited Talks:

  • Invited Speaker, Fairbanks Ethics Fellows’ Seminar : Ethics and Reproductive Technology, 2006, 2007, 2008.
  • Fertility Evaluation and Treatment Options after Childhood Cancer Therapy (Riley Children’s Cancer Survivor’s Day, September 10, 2005).
  • Preservation of Fertility in Female Cancer Patients: Oocyte and Ovarian Tissue Banking. (April 7, 2005)
  • ART and Embryo Law: Regulation of Reproductive Medicine and Research (February 2, 2005); part of the Embryo Law and Ethics Seminar.
  • Adolescent Sperm Banking Before Oncology Treatment (January 19, 2005)
  • Leadership in Health Care Student Program, St. Clair Hospital Lecture (March 10, 2000)
  • Reproductive Physiology Course Guest Lecturer, “The Diagnosis and Treatment of Infertility”, Duquesne University, Pittsburgh, PA (October  1997, November 1999)

Scientific Abstracts:

Once-a-day injection dosing for a mixed (FSH:HMG) stimulation protocol showed superior clinical outcomes compared to a twice-a-day dosing schedule. C.C. Wegner, J.J. Hudelson. B. Guth and W.L. Gentry. Advanced Fertility Group, IN 46280 and Evansville, IN 47714. Presented at ASRM Meeting, 2008 at San Francisco, CA.

Estradiol production from fresh and cryopreserved human ovarian tissue cultured in vitro.C. C. Wegner, P. M. Jilbert, W. L. Gentry, and M.A. HenryCenter for Reproductive Biology of Indiana, LLC., Indianapolis, IN 46280. Presented at Biosymposium: Oocytes, Ovary and Transplantation, Boston, Ma. September 2007. Values Fund Grant Support.

Better Ongoing Frozen Embryo Transfer Pregnancy Rates Using Vitrified Blastocysts . A.L. Clifford, P.M. Jilbert, W.L. Gentry, M.A. Henry and C.C. Wegner. .Center for Reproductive Biology of Indiana, LLC. Indianapolis, Indiana 46280. Presented   at ASRM meeting, 2007. Values Fund Grant Support.

Validation of Vitrification: Post-warming in vitro maturation and blastocyst outgrowth.  Patricia M. Villines, Alicia L. Clifford,  Michael A. Henry and Carole C. Wegner. Center for Reproductive Biology of Indiana, LLC. Indianapolis, Indiana 46280. Presented at ASRM meeting, 2006. Values Fund Grant Support.

Oocyte activation as a bioassay for functional viability of oocytes after vitrification. Patricia M. Villines, William L. Gentry and Carole C. Wegner, PhD. Clarian Reproductive Biology Laboratory. Indianapolis, Indiana 46280 Presented at ASRM meeting, 2005.Values Fund Grant Support.

Epididymal Sperm From the Obstructed Azoospermic Patient :Optimizing Pregnancy Rates While Reducing Multiple GestationCarole Wegner, Ph.D., Patricia M. Villines, Colin Terry M.S., William Gentry, M.D. and Samuel Thompson, M.D. Clarian Health Partners Reproductive Biology Laboratory, Methodist Research Institute and Urology of Indiana, Indianapolis, Indiana. Presented at ASRM Meeting 2004.

Professional Society Memberships:

Society of Reproductive Biologists and Technologists (Board Member)

Fertility Within Reach (Board Member)

American Society for Reproductive Medicine

European Society of Human Reproduction and Embryology (ESHERE)

American Association of Bioanalysts

Women In Bio, RTP Chapter

American Medical Writers Association